ZIKA Virus Research Reagents

ZIKA Virus
Zika fever is caused by an arbovirus belonging to the flavivirus genus of the Flaviviridae family, like the dengue virus. The insect vector is the Aedes female mosquito. The species currently able to spread the Zika virus is the Aedes aegypti. Aedes albopictus (tiger mosquito) could also prove to be a vector of the Zika virus, as it already transmits the dengue and chikungunya viruses.
ZIKA Mouse models
Vaccine and Pathogenesis Research

A research team at Washington University School of Medicine in St. Louis has established a mouse model for testing of vaccines and therapeutics to battle Zika virus.

The mouse model mimics aspects of the infection in humans, with high levels of the virus seen in the mouse brain and spinal cord, consistent with evidence showing that Zika causes neurological defects in human fetuses. Interestingly, the researchers detected the highest levels of the virus in the testes of male mice, a finding that supports clinical data indicating the virus can be sexually transmitted.

The new model of Zika virus infection, along with another recently identified by scientists at the University of Texas Medical Branch, are the first to be developed since 1976. The earlier models were not as clinically relevant because the infections were generated by injecting the virus directly into the brain. In the new models, infection occurs via the skin, much like the bite of the mosquito that spreads the virus.

Source: Washington University School of Medicine/The Source

Another article from a team at National Infection Service, Public Health England, UK report the demonstration that A129 mice are a susceptible mouse strain to ZIKV infection which we propose as a suitable and informative in vivo model for the testing of vaccines and therapeutics.

Research Reagents

Reagents for Non-Human Primates


SP856C - Zika Virus microplate
SPC856 - Simian Zika Virus Positive Control

Reagents for Mouse (Vaccine and Pathogenesis Research)


SP856C  - Zika Virus microplate
595-400 - Mouse Zika Virus Positive Control

 

The antigen is a recombinant NS-1 protein produced in HEK 293 Human cells. Sequence strain Uganda MR 766.

Other XpressBio NHPs Arbovirus Reagents:

West Nile Virus, Yellow Fever, Dengue and Chikungunya

Price list is at the Downloads page.

Products for Research Use Only. Please inquire about quantity discounts

ZIKA NHPs models
Vaccine and Pathogenesis Research
An alternative animal model* that mimics key features of the Zika virus infection has been developed at Texas Biomedical Research Institute in San Antonio. Acute infections in male marmosets, a New World monkey, resemble the human illness the Zika virus creates in people, including the presence of the virus in semen, saliva and urine up to two weeks after the initial infection.
*"Experimental Zika Virus Inoculation in a New World Monkey Model Reproduces Key Features of the Human Infection"

EUROPE
+ 33 675 88 10 59
thierry.delvienne@xpressbio.com

USA

+ 1 301-228-2444
888-562-8914 toll free

 

FOLLOW US:

  • Twitter Classic
  • Facebook Classic
  • LinkedIn Classic

© 2014 by DRT Consulting and XpressBio

 

Photography Credit: XpressBio
 

1,2,NIAID, Luca Voipi, Kat Masback, Daniel Paquet, Kaibara87, Umberto Salvagnin, ctomcsak, ciamabue, Global Panorama, AJ Cann, Duncan Hull, PAHO-WHO, Maarten, Francesco Paroni Sterbini, Nick Saltmarsh, AJC1, Carolfv333, Bilz0r? Kohlasz21, Nevit Dilmen, Emma Farmer, Jawahar Swaminathan